Clomid: Uses, Side Effects, Interactions, Warnings & Dosing


Clomid (clomiphene citrate) is a commonly prescribed medication for the treatment of infertility. It belongs to a class of drugs known as selective estrogen receptor modulators (SERMs). Clomid is primarily used in women to stimulate ovulation and increase the chances of pregnancy. However, it can also be prescribed for off-label uses in men with hormonal imbalances.

Uses of Clomid

Clomid is primarily used in the treatment of female infertility due to anovulation, which is the inability to release eggs from the ovaries. It works by blocking the effects of estrogen on the hypothalamus, a region of the brain that plays a crucial role in regulating the menstrual cycle. This results in increased production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which stimulate the growth and maturation of ovarian follicles.

Clomid is often the first line of treatment for women with polycystic ovary syndrome (PCOS), a common cause of infertility. It can also be prescribed for women with unexplained infertility or those undergoing assisted reproductive technologies such as in vitro fertilization (IVF).

Aside from its use in women, Clomid can also be prescribed off-label for men with hypogonadism, a condition where the body doesn’t produce enough testosterone. Clomid stimulates the release of gonadotropins, which in turn stimulate the testes to produce testosterone. It can be a safer and more cost-effective alternative to testosterone replacement therapy.

Side Effects of Clomid

Like any medication, Clomid can cause side effects. The most common side effects include:

  • Hot flashes
  • Headaches
  • Mood swings
  • Breast tenderness
  • Nausea

In rare cases, Clomid can cause more severe side effects, such as:

  • Visual disturbances
  • Abdominal pain
  • Shortness of breath
  • Ovarian hyperstimulation syndrome (OHSS)
  • Ectopic pregnancy

If you experience any of these symptoms, it is important to contact your healthcare provider immediately.

Interactions and Warnings

Clomid may interact with other medications, so it is important to inform your healthcare provider of all the medications you are taking. This includes prescription medications, over-the-counter drugs, and herbal supplements.

Clomid is contraindicated in women who are already pregnant, have liver disease, have a history of ovarian cysts, or have abnormal vaginal bleeding. It should also not be used for more than six cycles in a row as it may increase the risk of ovarian cancer.

Dosing of Clomid

The typical starting dose of Clomid for women is 50 milligrams (mg) per day for five days, usually starting on the fifth day of the menstrual cycle. If ovulation does not occur, the dose may be increased to 100 mg per day for five days in the next cycle. If ovulation still does not occur, further evaluation and alternative treatments may be needed.

For off-label use in men with hypogonadism, the typical starting dose of Clomid is 25 mg every other day, which may be adjusted based on hormone levels and response.


Clomid is a commonly prescribed medication for the treatment of infertility in women. It works by stimulating ovulation and increasing the chances of pregnancy. It can also be prescribed off-label for men with hormonal imbalances. While Clomid is generally safe and well-tolerated, it can cause side effects and may interact with other medications. It is important to follow the recommended dosing and consult with a healthcare provider if any side effects or concerns arise.